The Americans own a record of 2-2 with three drawn against La Celeste, the most recent meeting a 1-1 draw in 2019 at St. Louis.
US coach Gregg Berhalter’s squad will begin their training matches on June 1 at Cincinnati against Morocco before meeting an Uruguay lineup featuring all-time leading scorer Luis Suarez of Atletico Madrid and Edinson Cavani of Manchester United.
“We’re looking forward to facing another high-level opponent that is also preparing for the World Cup. Uruguay has some world-class talent and is one of the top teams in South America,” Berhalter said.
“These are the kinds of opportunities we need to continue to grow as a group and set ourselves up to be successful in Qatar.”
After hosting the South American squad, the Americans will host Grenada in a CONCACAF Nations League match on June 10 at Austin, Texas, and visit El Salvador four days later.
Uruguay reached the 2018 World Cup quarter-finals, losing to eventual champion France. The Uruguayans were drawn into this year’s Group H with Ghana, South Korea and Portugal.
The USA will play in Group B against England, Iran and either Scotland, Wales or Ukraine.